Competence Center for Systems Physiology and Metabolic Diseases

Stoffel, Markus, Prof.

Markus Stoffel

ETH Z├╝rich
Prof. Dr. Markus Stoffel
Inst. f. Molecular Health Sciences
HPL H 36
Schafmattstrasse 22
8093 Zuerich

Phone: +41 44 633 45 60
Fax: +41 44 633 13 62

Integration of extracellular hormonal and nutrient signals into comprehensive gene expression patterns leads to tightly choreographed phenotypic responses that regulate metabolism and differentiation. The overall research interest of the laboratory is to determine the fundamental genetic/biochemical mechanisms that regulate glucose and lipid metabolism through the study of transcriptional and translational regulators that control energy homeostasis. The importance of genetic regulation in the maintenance of glucose homeostasis is underscored by the many examples of aberrant signal transduction and transcriptional activation resulting in type 2 diabetes and the development of secondary complications.

Project opportunities for PhD students include:
1. Investigation of hormonal signaling during fasting, feeding and in type 2 diabetes.
2. Analysis of signals required for insulin secretion
3. Examination of growth promoting factors of pancreatic b-cells in physiological and pathological conditions
4. Studying the role of microRNAs in the regulation of gene expression in normal physiology and disease.
5. Investigation of HDL lipoprotein metabolism and its role in reverse cholesterol transport


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