Phone: +41 44 633 36 94
The phosphorylation network regulating metabolic activity in S. cerevisiae
In my project, I investigate the regulation of central carbon metabolism in the model organism yeast. Metabolic activity is regulated by complex regulatory circuits that span over DNA, RNA, proteins and small molecules. To understand the functional output of a metabolic network, it is important to decipher the various forms of communication that operate within the hierarchy of the regulatory levels. In my PHD, I focus on the role of reversible protein phosphorylation in the regulation of central carbon metabolism. Given the pivotal role of protein phosphorylation in cellular information processing and regulation, it can be anticipated that it is also a mechanism involved in the control of metabolic activity. Indeed, several individual cases of direct regulatory phosphorylation of metabolic enzymes are well known. Applying metabolomics, I will monitor the metabolic response of phosphorylation mutants to genetic and environmental perturbation. The obtained data will be mapped with available networks of protein interactions, phosphoproteomics and transcription.
I am a member of the Uwe Sauer group.
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